Hemostasis, Thrombosis, and Vascular Biology
نویسندگان
چکیده
Elevated levels of plasma homocysteine (Hcy) correlate with increased risk of cardiovascular and Alzheimer diseases. We studied the effect of elevated Hcy on the blood-brain barrier (BBB) to explore the possibility of a vascular link between the 2 diseases. On a hyperhomocysteinemic diet, cystathionine beta-synthase (Cbs)– heterozygous mice develop hyperhomocysteinemia. Intravital microscopy analysis of the mesenteric venules showed that leukocyte rolling velocity was markedly decreased and numbers of adherent cells were increased in the mutant mice. This was due at least in part to increased expression of P-selectin. BBB permeability was measured by Evans blue dye permeation and was found to be 25% greater in the Cbs / cortex compared with wild-type controls. Our study suggests an important toxic effect of elevated Hcy on brain microvessels and implicates Hcy in the disruption of the BBB. (Blood. 2006;107:591-593)
منابع مشابه
Comparison of Celox powder and conventional dressing on hemostasis of vascular access site in hemodialysis patients
Background: Common measures to stop bleeding can run the risk of clotting and thrombosis due to prolonged application of pressure. Topical homeostatic agents have an important role in decreasing time to hemostasis and consequently prevention of the complications. Aim: the aim of this study was to compare Celox powder and conventional bandage on time to hemostasis in the vascular access site i...
متن کاملIntelligent platelet inhibitors are on the horizon.
Hemostasis is a tightly regulated physiological sequence of events that maintains vascular integrity and imminent blood loss after vessel injury. Platelets play a critical role in primary hemostasis and in regulation of coagulation. Under physiological conditions, hemostasis and thrombosis are in a fragile equilibrium. Uncontrolled platelet activation leads to intravascular thrombosis and organ...
متن کاملIntrinsic pathway of coagulation and arterial thrombosis.
Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that may occlude vessels (thrombosis). Many antithrombotic drugs target key elements of the plasma coagulation mechanis...
متن کاملRole of tissue factor in hemostasis, thrombosis, and vascular development.
Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. TF deficiency causes embryonic lethality in the mouse and there have been no reports of TF deficiency in humans. These results indicate that TF is essential for...
متن کاملComputational approaches to studying thrombus development.
In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of ...
متن کاملMinimal functional model of hemostasis in a biomimetic microfluidic system.
Biology is functional, and this function both inspires and puzzles. Inspiration from biology has led to the development of biomimetic systems—artificial systems that function by mimicking biology. Biomimetic systems have been successfully created in self-assembly, 2] materials, chemical synthesis, and surface chemistry. They often provide insight into the puzzles of biology, because to develop ...
متن کامل